4npq

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'''Unreleased structure'''
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{{STRUCTURE_4npq| PDB=4npq | SCENE= }}
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===The resting-state conformation of the GLIC ligand-gated ion channel===
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The entry 4npq is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
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Authors: Sauguet, L., Shahsavar, A, Poitevin, F., Huon, C., Menny, A., Nemecz, A., Haouz, A., Changeux, J.P., Corringer, P.J., Delarue, M.
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==About this Structure==
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[[4npq]] is a 20 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPQ OCA].
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Description: The resting-state conformation of the GLIC ligand-gated ion channel
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Changeux, J P.]]
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[[Category: Corringer, P J.]]
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[[Category: Delarue, M.]]
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[[Category: Haouz, A.]]
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[[Category: Huon, C.]]
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[[Category: Menny, A.]]
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[[Category: Nemecz, A.]]
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[[Category: Poitevin, F.]]
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[[Category: Sauguet, L.]]
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[[Category: Shahsavar, A]]
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[[Category: Pentameric ligand-gated ion channel]]
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[[Category: Ph-gated]]
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[[Category: Transmembrane]]
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[[Category: Transport protein]]

Revision as of 10:30, 25 December 2013

Template:STRUCTURE 4npq

Contents

The resting-state conformation of the GLIC ligand-gated ion channel

Function

[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]

About this Structure

4npq is a 20 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

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OCA

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