4nr8

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m (Protected "4nr8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4nr8| PDB=4nr8 | SCENE= }}
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===Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand===
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The entry 4nr8 is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Hay, D., Fedorov, O., Martin, S., Von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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==Function==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Description: Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand
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==About this Structure==
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[[4nr8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NR8 OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Brennan, P.]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards, A M.]]
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[[Category: Fedorov, O.]]
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[[Category: Felletar, I.]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Hay, D.]]
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[[Category: Knapp, S.]]
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[[Category: Martin, S.]]
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[[Category: Picaud, S.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Chemical tool]]
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[[Category: Sgc]]
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[[Category: Small molecule inhibitor]]
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[[Category: Structural genomics consortium]]
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[[Category: Transcription]]
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[[Category: Transcription-inhibitor complex]]

Revision as of 10:30, 25 December 2013

Template:STRUCTURE 4nr8

Contents

Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4nr8 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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