Adenosine kinase (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog. AdK deficiency causes hypermethioninemia.
3D structures of adenosine kinase
1lio – TgAdK – Toxoplasma gondii
Adenosine kinase binary complex
1bx4 – hAdK + adenosine - human
2i6a, 2i6b – hAdK + prodrug
1dgm, 1lik – TgAdK + adenosine
2a9y – TgAdK (mutant) + dimethyladenosine
2abs – TgAdK (mutant) + AMP-PCP
2aa0 – TgAdK (mutant) + methylthiopurine
2pkk – MtAdK + fluoroadenosine – Mycobacterium tuberculosis
2pkn – MtAdK + AMP-PCP
2pkm – MtAdK + adenosine
Adenosine kinase ternary complex
2a9z – TgAdK (mutant) + adenosine + AMP-PCP
2a9z – TgAdK (mutant) + dimethyladenosine + AMP-PCP
1lij – TgAdK + prodrug + AMP-PCP
2ab8 – TgAdK (mutant) + methylthiopurine + AMP-PCP
