S-adenosylhomocysteine hydrolase

S-adenosylhomocysteine hydrolase (AHCH) converts S-adenosylhomocysteine (AdoHcy) to L-homocysteine and adenosine. AHCH uses NAD+ as cofactor. AHCH is an essential enzyme in processes like transmethylation, trans-sulfuration and purine metabolism.

3D structures of S-adenosylhomocysteine hydrolase

Updated on 26-December-2013

1ky4 – rAHCH + NAD - rat

1ky5 – rAHCH (mutant) + NAD
1b3r – rAHCH catalytic domain + NAD
1a7a – hAHCH + NAD – human
3d64 – BpAHCH + NAD – Burkholderia pseudmallei

AHCH complex with adenosine derivatives

1d4f, 1xwf – rAHCH (mutant) + NAD + adenosine

1k0u, 2h5l – rAHCH + NAD + adenosine analog
1li4, 3nj4 – hAHCH + NAD + adenosine derivative
1v8b – AHCH + NAD + adenosine – Plasmodium falciparum
3dhy, 2ziz, 2zj0, 2zj1 – MtAHCH + NAD + adenosine derivative – Mycobacterium tuberculosis
3ce6 – MtAHCH + NAD + adenosine
3glq – BpAHCH + NAD + adenosine derivative
3n58 – AHCH + NAD + adenosine – Brucella melitensis
3ond – lAHCH + NAD + adenosine – lupin
3one – lAHCH + NAD + adenine
3onf – lAHCH + NAD + adenosine derivative