Sandbox Reserved 820

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{{Sandbox_Reserved_ESBS}}
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<Structure load='2vaf' size='500' frame='true' align='right' caption='Crystal Structure of Human Cardiac Calsequestrin, (PDB code [[2vaf]]) ' scene='56/568018/General_structure/4'/>
<Structure load='2vaf' size='500' frame='true' align='right' caption='Crystal Structure of Human Cardiac Calsequestrin, (PDB code [[2vaf]]) ' scene='56/568018/General_structure/4'/>
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Calsequestrin-2 (or CASQ2) is the soluble CA2+ binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca2+. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.
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'''Calsequestrin-2''' (or '''CASQ2''') is the soluble CA2+ binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca2+. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.
[[Image:LoadBinary 004.gif|300px|left|thumb|Calsequestrin in the calcium cycle of myocyte contraction]]
[[Image:LoadBinary 004.gif|300px|left|thumb|Calsequestrin in the calcium cycle of myocyte contraction]]
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{{clear}}
== General Structure ==
== General Structure ==
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There are <scene name='56/568018/Alpha_helix/1'>12 alpha helix</scene> and <scene name='56/568018/Beta_sheet/2'>15 beta sheet</scene>.
There are <scene name='56/568018/Alpha_helix/1'>12 alpha helix</scene> and <scene name='56/568018/Beta_sheet/2'>15 beta sheet</scene>.
<scene name='56/568018/Acidic_amino_acids/1'>The acidics amino acids</scene> can bind the Ca2+ especially the <scene name='56/568018/Glu/1'>glutamate</scene> and the <scene name='56/568018/Asp/1'>aspartate</scene>.
<scene name='56/568018/Acidic_amino_acids/1'>The acidics amino acids</scene> can bind the Ca2+ especially the <scene name='56/568018/Glu/1'>glutamate</scene> and the <scene name='56/568018/Asp/1'>aspartate</scene>.

Revision as of 13:20, 29 December 2013

This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
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  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
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More help: Help:Editing

Crystal Structure of Human Cardiac Calsequestrin, (PDB code 2vaf)

Drag the structure with the mouse to rotate

Calsequestrin-2 (or CASQ2) is the soluble CA2+ binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca2+. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia.

Calsequestrin in the calcium cycle of myocyte contraction
Calsequestrin in the calcium cycle of myocyte contraction

General Structure

There are and . can bind the Ca2+ especially the and the .

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