Phosphoserine aminotransferase
From Proteopedia
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[[1bt4]], [[1w3u]], [[2c0r]] – PSAT (mutant) + PLP – ''Bacillus circulans''<br /> | [[1bt4]], [[1w3u]], [[2c0r]] – PSAT (mutant) + PLP – ''Bacillus circulans''<br /> | ||
[[1bjn]] – EcPSAT + PLP – ''Escherichia coli''<br /> | [[1bjn]] – EcPSAT + PLP – ''Escherichia coli''<br /> | ||
| - | [[1w23]], [[2bhx]], [[2bi1]], [[2bi2]], [[2bi3]], [[2bi5]], [[2bi9]], [[2bia]], [[2bie]], [[2big]] - PSAT + PLP – ''Bacillus alcalophilus''<br /> | + | [[1w23]], [[2bhx]], [[2bi1]], [[2bi2]], [[2bi3]], [[2bi5]], [[2bi9]], [[2bia]], [[2bie]], [[2big]], [[4azj]], [[4azk]] - PSAT + PLP – ''Bacillus alcalophilus''<br /> |
[[3e77]] – PSAT + PLP – human<br /> | [[3e77]] – PSAT + PLP – human<br /> | ||
[[3ffr]] – PSAT + PLP – ''Cytophaga hutchinsonii''<br /> | [[3ffr]] – PSAT + PLP – ''Cytophaga hutchinsonii''<br /> | ||
Revision as of 09:10, 30 December 2013
Phosphoserine aminotransferase (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT. PSAT is over-expressed in colon tumors and its inhibition is being tested as drug treatment.
3D structures of phosphoserine aminotransferase
3m5u – PSAT – Campylobacter jejuni
3qm2 – PSAT – Salmonella enterica
Phosphoserine aminotransferase complex with pyridoxal phosphate
1bt4, 1w3u, 2c0r – PSAT (mutant) + PLP – Bacillus circulans
1bjn – EcPSAT + PLP – Escherichia coli
1w23, 2bhx, 2bi1, 2bi2, 2bi3, 2bi5, 2bi9, 2bia, 2bie, 2big, 4azj, 4azk - PSAT + PLP – Bacillus alcalophilus
3e77 – PSAT + PLP – human
3ffr – PSAT + PLP – Cytophaga hutchinsonii
3qbo – PSAT + PLP
Phosphoserine aminotransferase ternary complex
1bjo - EcPSAT + α-methyl-glutamate + PLP
