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Sandbox Reserved 825

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=='''FRB Domain'''==
=='''FRB Domain'''==
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mTOR is highly conserved across all eukaryotes, with 40–60% amino-acid sequence identity.
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The mammalian target of rapamycin (mTOR) is a protein that is intricately involved in signaling pathways controlling cell growth. Rapamycin is a natural product that binds and inhibits mTOR function by interacting with its FKBP-rapamycin-binding (FRB) domain (or '''2NPU''')
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mTOR contains a number of distinct functional domains including up to''' The FRB domain''' of '''mTOR''' (or '''2NPU''') which is responsible for the binding of the inhibitory cyclic macrolide '''Rapamycin'''
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mTOR is highly conserved across all eukaryotes, with 40–60% amino-acid sequence identity.

Revision as of 13:24, 30 December 2013

This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
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Contents

FRB Domain

The mammalian target of rapamycin (mTOR) is a protein that is intricately involved in signaling pathways controlling cell growth. Rapamycin is a natural product that binds and inhibits mTOR function by interacting with its FKBP-rapamycin-binding (FRB) domain (or 2NPU)

mTOR is highly conserved across all eukaryotes, with 40–60% amino-acid sequence identity.

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