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4hn4
From Proteopedia
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{{STRUCTURE_4hn4| PDB=4hn4 | SCENE= }} | {{STRUCTURE_4hn4| PDB=4hn4 | SCENE= }} | ||
===Tryptophan synthase in complex with alpha aminoacrylate E(A-A) form and the F9 inhibitor in the alpha site=== | ===Tryptophan synthase in complex with alpha aminoacrylate E(A-A) form and the F9 inhibitor in the alpha site=== | ||
| + | {{ABSTRACT_PUBMED_23952479}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4hn4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HN4 OCA]. | [[4hn4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HN4 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023952479</ref><references group="xtra"/><references/> | ||
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]] | [[Category: Salmonella enterica subsp. enterica serovar typhimurium]] | ||
[[Category: Tryptophan synthase]] | [[Category: Tryptophan synthase]] | ||
Revision as of 10:47, 1 January 2014
Contents |
Tryptophan synthase in complex with alpha aminoacrylate E(A-A) form and the F9 inhibitor in the alpha site
Template:ABSTRACT PUBMED 23952479
Function
[TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [TRPB_SALTY] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
About this Structure
4hn4 is a 2 chain structure with sequence from [1] and Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA.
Reference
- Niks D, Hilario E, Dierkers A, Ngo H, Borchardt D, Neubauer TJ, Fan L, Mueller LJ, Dunn MF. Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry. 2013 Sep 17;52(37):6396-411. doi: 10.1021/bi400795e. Epub 2013 Sep , 6. PMID:23952479 doi:http://dx.doi.org/10.1021/bi400795e
Categories: Salmonella enterica subsp. enterica serovar typhimurium | Tryptophan synthase | Dunn, M F. | Fan, L. | Hilario, E. | Mueller, L J. | Niks, D. | Allosteric enzyme | Alpha amino acrylate | Amino-acid biosynthesis | Aromatic amino acid biosynthesis | Carbon-oxygen lyase | F9f | Lyase | Lyase-lyase inhibitor complex | Pyridoxal phosphate | Salmonella | Tryptophan biosynthesis
