2kzg

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[[Image:2kzg.png|left|200px]]
 
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{{STRUCTURE_2kzg| PDB=2kzg | SCENE= }}
{{STRUCTURE_2kzg| PDB=2kzg | SCENE= }}
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===A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution===
===A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution===
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{{ABSTRACT_PUBMED_20829478}}
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{{ABSTRACT_PUBMED_20829478}}
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==Function==
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[[http://www.uniprot.org/uniprot/PR40A_HUMAN PR40A_HUMAN]] Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.<ref>PMID:21834987</ref>
==About this Structure==
==About this Structure==
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[[2kzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZG OCA].
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[[2kzg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZG OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:020829478</ref><references group="xtra"/>
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<ref group="xtra">PMID:020829478</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Banachewicz, W.]]
[[Category: Banachewicz, W.]]
[[Category: Fersht, A R.]]
[[Category: Fersht, A R.]]

Revision as of 10:51, 1 January 2014

Template:STRUCTURE 2kzg

Contents

A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution

Template:ABSTRACT PUBMED 20829478

Function

[PR40A_HUMAN] Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.[1]

About this Structure

2kzg is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Korzhnev DM, Religa TL, Banachewicz W, Fersht AR, Kay LE. A transient and low-populated protein-folding intermediate at atomic resolution. Science. 2010 Sep 10;329(5997):1312-6. PMID:20829478 doi:10.1126/science.1191723
  1. ↑ Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V, Suryavanshi N, Bechtel S, Wiemann S, Baum B, Ridley AJ. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol. 2011 Aug 11;9:54. doi: 10.1186/1741-7007-9-54. PMID:21834987 doi:10.1186/1741-7007-9-54

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