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4o38

From Proteopedia

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m (Protected "4o38" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4o38| PDB=4o38 | SCENE= }}
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===Crystal structure of the human cyclin G associated kinase (GAK)===
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The entry 4o38 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN]] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref>
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Authors: Zhang, R., Hatzos-Skintges, C., Weger, A., Chaikuad, A., Eswaran, J., Fedorov, O., King, O., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Joachimiak, A., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4o38]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ll6 3ll6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O38 OCA].
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Description: Crystal structure of the human cyclin G associated kinase (GAK)
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Chaikuad, A.]]
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[[Category: Delft, F von.]]
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[[Category: Edwards, A.]]
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[[Category: Eswaran, J.]]
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[[Category: Fedorov, O.]]
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[[Category: Hatzos-Skintges, C.]]
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[[Category: Joachimiak, A.]]
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[[Category: King, O.]]
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[[Category: Knapp, S.]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Weger, A.]]
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[[Category: Weigelt, J.]]
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[[Category: Zhang, R.]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Cell junction]]
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[[Category: Clathrine]]
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[[Category: Cyclin g]]
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[[Category: Golgi apparatus]]
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[[Category: Kinase]]
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[[Category: Mcsg]]
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[[Category: Membrane trafficking]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Nucleotide-binding]]
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[[Category: P53]]
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[[Category: Phosphoprotein]]
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[[Category: Protein kinase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Serine/threonine kinase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]

Revision as of 12:04, 1 January 2014

Template:STRUCTURE 4o38

Contents

Crystal structure of the human cyclin G associated kinase (GAK)

Function

[GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.[1]

About this Structure

4o38 is a 2 chain structure. This structure supersedes the now removed PDB entry 3ll6. Full crystallographic information is available from OCA.

Reference

  1. ↑ Greener T, Zhao X, Nojima H, Eisenberg E, Greene LE. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem. 2000 Jan 14;275(2):1365-70. PMID:10625686

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OCA

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