4nbk

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Revision as of 07:42, 13 November 2013 (edit) OCA (Talk | contribs) ← Previous diff		Revision as of 12:06, 1 January 2014 (edit) (undo) OCA (Talk | contribs) Next diff →
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-	'''Unreleased structure'''	+	{{STRUCTURE_4nbk| PDB=4nbk | SCENE= }}
		+	===Tailoring Small Molecules for an Allosteric Site on Procaspase-6===
		+	{{ABSTRACT_PUBMED_24259468}}
-	The entry 4nbk is ON HOLD	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
-	Authors: Murray, J.M., Steffek, M.	+	==About this Structure==
		+	[[4nbk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NBK OCA].
-	Description: Tailoring Small Molecules for an Allosteric Site on Procaspase-6	+	==Reference==
		+	<ref group="xtra">PMID:024259468</ref><references group="xtra"/><references/>
		+	[[Category: Caspase-6]]
		+	[[Category: Murray, J M.]]
		+	[[Category: Steffek, M.]]
		+	[[Category: Allosteric]]
		+	[[Category: Caspase-6 zymogen]]
		+	[[Category: Cysteine protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Procaspse-6]]
		+	[[Category: Structure based drug design]]

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Revision as of 12:06, 1 January 2014

Template:STRUCTURE 4nbk

Contents 1 Tailoring Small Molecules for an Allosteric Site on Procaspase-6 2 Function 3 About this Structure 4 Reference

Tailoring Small Molecules for an Allosteric Site on Procaspase-6

Template:ABSTRACT PUBMED 24259468

Function

[CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

About this Structure

4nbk is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

• Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Tailoring Small Molecules for an Allosteric Site on Procaspase-6. ChemMedChem. 2013 Nov 20. doi: 10.1002/cmdc.201300424. PMID:24259468 doi:http://dx.doi.org/10.1002/cmdc.201300424