4jvj

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'''Unreleased structure'''
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{{STRUCTURE_4jvj| PDB=4jvj | SCENE= }}
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===Crystal structure of human FPPS in complex with magnesium, CL01131, and sulfate===
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{{ABSTRACT_PUBMED_23998921}}
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The entry 4jvj is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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Authors: Park, J., Leung, C.-Y., Tsantrizos, Y.S., Berghuis, A.M.
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==About this Structure==
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[[4jvj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVJ OCA].
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Description: Crystal structure of human FPPS in complex with magnesium, CL01131, and sulfate
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==Reference==
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<ref group="xtra">PMID:023998921</ref><references group="xtra"/><references/>
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[[Category: Berghuis, A M.]]
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[[Category: Leung, C Y.]]
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[[Category: Park, J.]]
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[[Category: Tsantrizos, Y S.]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 12:06, 1 January 2014

Template:STRUCTURE 4jvj

Contents

Crystal structure of human FPPS in complex with magnesium, CL01131, and sulfate

Template:ABSTRACT PUBMED 23998921

Function

[FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

About this Structure

4jvj is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Leung CY, Park J, De Schutter JW, Sebag M, Berghuis AM, Tsantrizos YS. Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition. J Med Chem. 2013 Oct 3. PMID:23998921 doi:http://dx.doi.org/10.1021/jm400946f

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OCA

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