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4ia0

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'''Unreleased structure'''
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{{STRUCTURE_4ia0| PDB=4ia0 | SCENE= }}
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===Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors===
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{{ABSTRACT_PUBMED_23867165}}
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The entry 4ia0 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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Authors: Ren, J., Chen, T.T., Xu, Y.C.
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==About this Structure==
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[[4ia0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IA0 OCA].
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Description: Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
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==Reference==
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<ref group="xtra">PMID:023867165</ref><references group="xtra"/><references/>
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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[[Category: Chen, T.]]
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[[Category: Ren, J.]]
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[[Category: Xu, Y.]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 12:08, 1 January 2014

Template:STRUCTURE 4ia0

Contents

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

Template:ABSTRACT PUBMED 23867165

Function

[PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.

About this Structure

4ia0 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. , Epub 2013 Jun 29. PMID:23867165 doi:http://dx.doi.org/10.1016/j.bmcl.2013.06.062

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OCA

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