We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2bi7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 24: Line 24:
[[Category: lipopolysaccharide biosynthesis]]
[[Category: lipopolysaccharide biosynthesis]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:17:27 2007''
+
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:38:39 2007''

Revision as of 14:33, 30 October 2007

Image:2bi7.gif

2bi7, resolution 2.00Å

Drag the structure with the mouse to rotate

UDP-GALACTOPYRANOSE MUTASE FROM KLEBSIELLA PNEUMONIAE OXIDISED FAD

Overview

Uridine diphosphogalactofuranose (UDP-Galf) is the precursor of the, d-galactofuranose sugar found in bacterial and parasitic cell walls, including those of many pathogens. UDP-Galf is made from, UDP-galactopyranose by the enzyme UDP-galactopyranose mutase. The enzyme, requires the reduced FADH- co-factor for activity. The structure of the, Mycobacterium tuberculosis mutase with FAD has been determined to 2.25 A., The structures of Klebsiella pneumoniae mutase with FAD and with FADH-, bound have been determined to 2.2 A and 2.35 A resolution, respectively., This is the first report of the FADH(-)-containing structure. Two, flavin-dependent mechanisms for the enzyme have been proposed, one, which, involves a covalent adduct being formed at the flavin and the other based, on electron ... [(full description)]

About this Structure

2BI7 is a [Single protein] structure of sequence from [Klebsiella pneumoniae] with FAD as [ligand]. This structure superseeds the now removed PDB entry 1USJ. Active as [UDP-galactopyranose mutase], with EC number [5.4.99.9]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state., Beis K, Srikannathasan V, Liu H, Fullerton SW, Bamford VA, Sanders DA, Whitfield C, McNeil MR, Naismith JH, J Mol Biol. 2005 May 13;348(4):971-82. PMID:15843027

Page seeded by OCA on Tue Oct 30 16:38:39 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bi7"
Personal tools