4j7y

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'''Unreleased structure'''
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{{STRUCTURE_4j7y| PDB=4j7y | SCENE= }}
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===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis===
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The entry 4j7y is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
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Authors: Niegowski, D., Rinaldo-Matthis, A., Haeggstrom, J.Z.
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==Function==
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[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
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Description: Human LTC4 synthase in complex with product analogs -implications for enzyme catalysis
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==About this Structure==
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[[4j7y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7Y OCA].
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[[Category: Haeggstrom, J Z.]]
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[[Category: Niegowski, D.]]
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[[Category: Rinaldo-Matthis, A.]]
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[[Category: Leukotriene c4 synthase]]
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[[Category: Lipid biosynthesis]]
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[[Category: Lyase]]
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[[Category: Product analog]]

Revision as of 12:13, 1 January 2014

Template:STRUCTURE 4j7y

Contents

Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis

Disease

[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

Function

[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

About this Structure

4j7y is a 1 chain structure. Full crystallographic information is available from OCA.

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OCA

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