4myq

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'''Unreleased structure'''
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{{STRUCTURE_4myq| PDB=4myq | SCENE= }}
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===Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33===
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The entry 4myq is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
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Authors: Fox III, D., Edwards, T.E.
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==About this Structure==
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[[4myq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MYQ OCA].
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Description: PDE4 catalytic domain
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==Reference==
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<references group="xtra"/><references/>
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Edwards, T E.]]
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[[Category: III, D Fox.]]
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[[Category: Catalytic]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Phosphodiesterase]]

Revision as of 12:15, 1 January 2014

Template:STRUCTURE 4myq

Contents

Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33

Function

[PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.[1] [2]

About this Structure

4myq is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT. Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity. Science. 2000 Jun 9;288(5472):1822-5. PMID:10846163
  2. ↑ Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT. Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J Mol Biol. 2004 Mar 19;337(2):355-65. PMID:15003452 doi:http://dx.doi.org/10.1016/j.jmb.2004.01.040

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OCA

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