Tryptophan synthase
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_1wbj| PDB=1wbj | SIZE=400| SCENE=|right|CAPTION=Tryptophan synthase α subunit (grey) and β subunit (green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion [[1wbj]]}} | + | {{STRUCTURE_1wbj| PDB=1wbj | SIZE=400| SCENE=|right|CAPTION=Tryptophan synthase α subunit (grey) and β subunit (green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) [[1wbj]]}} |
'''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide. | '''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide. | ||
Revision as of 11:27, 2 January 2014
Tryptophan synthase (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide.
Contents |
3D structures of tryptophan synthase
Updated on 02-January-2014
1x1q - TtTrpS β subunit – Thermus thermophilus
2dh6 - EcTrpS β subunit]] - Escherichia coli
2o2e, 2o2j - TrpS β subunit – Mycobacterium tuberculosis
3vnd - TrpS α subunit – Shewanella frigidimarina
3tha - TrpS α subunit – Campylobacter jejuni
3nav - TrpS α subunit – Vibrio cholerae
TrpS binary complex
2dh5 - EcTrpS β subunit + PLP
1ttp, 1ttq, 1bks, 2wsy, 1kfk - StTrpS α + β + PLP – Salmonella typhimurium
1a5a, 1k8x - StTrpS α (mutant) + β + PLP
1k7x, 2j9z - StTrpS α + β (mutant) + PLP
2tys - StTrpS α (mutant) + β (mutant) + Trp derivative
1kfe - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate
1kfj - StTrpS α + β + pyridoxal-serine-monophsphate
2j9y - StTrpS α + β (mutant) + enoic acid derivative
3pr2 - StTrpS α + β + inhibitor
TrpS ternary complex with PLP and inhibitor
1a50, 1cw2, 1c9d, 1cx9, 1c8v, 1c29, 2cle, 2clh, 2cli, 2clk, 2cll, 2clm, 2clo, 2clf - StTrpS α + β + inhibitor + PLP
1fuy - StTrpS α + β (mutant) + inhibitor + PLP
TrpS ternary complex with PLP and IGP derivatives
1a5b, 1kfb - StTrpS α (mutant) + β + IGP + PLP
1k8z - StTrpS α + β (mutant) + IGP derivative + PLP
1kfc - StTrpS α (mutant) + β + IGP derivative + PLP
1k3u, 1k7e, 1k7f - StTrpS α + β + IGP derivative + PLP
1qoq, 2rh9, 2rhg - StTrpS α + β + IGP + PLP
1qop - StTrpS α + β + IGP analog + PLP
2trs, 1beu - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
TrpS ternary complex with PLP and G3P derivatives
1wbj - StTrpS α + β + G3P + PLP
2j9x - StTrpS α + β + G3P + acrylic acid derivative
1k8y - StTrpS α + β (mutant) + G3P derivative + PLP
1tjp - StTrpS α + β + G3P derivative + PLP
2tsy - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P
1ubs - StTrpS α (mutant) + β (mutant) + serine + PLP
TrpS quaternary complex
1a5s - StTrpS α + β + serine + inhibitor + PLP
3cep - StTrpS α + β + G3P + indoline + PLP
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Amer Ali
