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| - | TraR is a quorum sensing protein in Agrobacterium tumefaciens. Shown is TraR bound to its autoinducer 3-oxooctanoyl-homoserine lactone (OOHL) [3] and target DNA. | + | TraR is a quorum sensing protein in Agrobacterium tumefaciens. Shown is TraR bound to its autoinducer 3-oxooctanoyl-homoserine lactone (OOHL)[3], also called Agrobacterium autoinducer (AAI) [4], and its target DNA. |
| - | Quorum sensing is used by bacteria to regulate | + | Quorum sensing is used by bacteria to regulate gene expression depending on cell-population density [1]. Therefore Bacteria use small hormone-like proteins called autoinducers [2]. These autoinducers increase in concentration with increasing cell density [1]. Reaching a minimal threshold stimulatory concentration, the autoinducers activate gene regulation processes by interaction with transcription factors [1]. This quorum sensing becomes beneficial as soon as it is performed by many cells [2]. |
| - | Quorum sensing is used by Gram-negative | + | Quorum sensing is used by Gram-negative as well as Gram-positive bacteria and occurs within and between bacterial species [1]. The communication via quorum sensing may have been a first step of multi-cellularity and makes the distinction between eukaryotes and prokaryotes more complex [1, 2]. |
| - | TraR is member of the quorum-sensing transcription factor family called LuxR [3]. In presence of its autoinducer | + | TraR is member of the quorum-sensing transcription factor family called LuxR [3]. In presence of its autoinducer AAI, TraR regulates genes connected to the tumor inducing (Ti) plasmid [3]. Absence of its autoinducer causes rapid proteolysis of TraR [3], which implies that TraR saves the protein from degradation [4]. |
N-ter Region : <scene name='57/574296/N-ter/1'>N-terminal region</scene> | N-ter Region : <scene name='57/574296/N-ter/1'>N-terminal region</scene> | ||
| - | linker: <scene name='57/574296/Linker/ | + | linker: <scene name='57/574296/Linker/1'>Linker</scene> |
Dimer: <scene name='57/574296/Dimer/1'>Dimer</scene> | Dimer: <scene name='57/574296/Dimer/1'>Dimer</scene> | ||
Ligand: <scene name='57/574296/Ligand/1'>Ligand</scene> | Ligand: <scene name='57/574296/Ligand/1'>Ligand</scene> | ||
Ligand Binding Site: <scene name='57/574296/Ligand_binding_site/1'>Ligand Binding Site</scene> | Ligand Binding Site: <scene name='57/574296/Ligand_binding_site/1'>Ligand Binding Site</scene> | ||
| - | neg charge dna binding <scene name='57/574296/Neg_charged_dna_binding_region/1'>negatively charged</scene> | ||
Revision as of 20:43, 6 January 2014
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The quorum sensing protein TraR
Description
Shown is bound to its autoinducer 3-oxooctanoyl-homoserine lactone (OOHL) [3] and .
TraR is a quorum sensing protein in Agrobacterium tumefaciens. Shown is TraR bound to its autoinducer 3-oxooctanoyl-homoserine lactone (OOHL)[3], also called Agrobacterium autoinducer (AAI) [4], and its target DNA.
Quorum sensing is used by bacteria to regulate gene expression depending on cell-population density [1]. Therefore Bacteria use small hormone-like proteins called autoinducers [2]. These autoinducers increase in concentration with increasing cell density [1]. Reaching a minimal threshold stimulatory concentration, the autoinducers activate gene regulation processes by interaction with transcription factors [1]. This quorum sensing becomes beneficial as soon as it is performed by many cells [2].
Quorum sensing is used by Gram-negative as well as Gram-positive bacteria and occurs within and between bacterial species [1]. The communication via quorum sensing may have been a first step of multi-cellularity and makes the distinction between eukaryotes and prokaryotes more complex [1, 2].
TraR is member of the quorum-sensing transcription factor family called LuxR [3]. In presence of its autoinducer AAI, TraR regulates genes connected to the tumor inducing (Ti) plasmid [3]. Absence of its autoinducer causes rapid proteolysis of TraR [3], which implies that TraR saves the protein from degradation [4].
N-ter Region : linker: Dimer:
Ligand: Ligand Binding Site:
