Sandbox Reserved 816
From Proteopedia
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'''Internalin K''' is a protein from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] | '''Internalin K''' is a protein from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] | ||
| - | , which is a Gram-positive bacterium human pathogen. Its ability to survive in the human intestine and to cross a variety of membranes, including mucosal, intestinal, placental, and blood–brain barriers, allows it to generate illnesses ranging from gastroenteritis in healthy individuals to bacteremia and meningitis in immunocompromised patients, as well as mother-to-child infections. [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] can survive in a variety of cell types and proteins of the internalin family have been shown to play a key role in this survival. | + | , which is a [http://en.wikipedia.org/wiki/Gram-positive_bacteria Gram-positive bacterium] human pathogen. Its ability to survive in the human intestine and to cross a variety of membranes, including mucosal, intestinal, placental, and blood–brain barriers, allows it to generate illnesses ranging from gastroenteritis in healthy individuals to bacteremia and meningitis in immunocompromised patients, as well as mother-to-child infections. [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] can survive in a variety of cell types and proteins of the internalin family have been shown to play a key role in this survival. |
| - | + | '''Internalin K''' is involved in [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] ability to escape from autophagy by recruitment of [http://en.wikipedia.org/wiki/Major_vault_protein major vault protein] to the bacterial surface. | |
| - | Internalin K is a four-domain protein with a “bent arm” morphology. The recognition of [http://en.wikipedia.org/wiki/Major_vault_protein major vault protein] domain is locatized at the “elbow” region. | ||
| - | <Structure load='4l3a' size='500' frame='true' align='right' caption='Internalin K dimer' scene='Insert optional scene name here' /> | ||
<scene name='56/568014/D1/1'>D1</scene> | <scene name='56/568014/D1/1'>D1</scene> | ||
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[http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] | [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogene] | ||
| + | [http://en.wikipedia.org/wiki/Gram-positive_bacteria Gram-positive bacterium] | ||
<scene name='56/568014/Major_vault_protein/1'>MVP</scene> | <scene name='56/568014/Major_vault_protein/1'>MVP</scene> | ||
Revision as of 17:48, 7 January 2014
| This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543. |
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Introduction
Internalin K is a protein from Listeria monocytogene , which is a Gram-positive bacterium human pathogen. Its ability to survive in the human intestine and to cross a variety of membranes, including mucosal, intestinal, placental, and blood–brain barriers, allows it to generate illnesses ranging from gastroenteritis in healthy individuals to bacteremia and meningitis in immunocompromised patients, as well as mother-to-child infections. Listeria monocytogene can survive in a variety of cell types and proteins of the internalin family have been shown to play a key role in this survival.
Internalin K is involved in Listeria monocytogene ability to escape from autophagy by recruitment of major vault protein to the bacterial surface.
