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TraR is a quorum sensing protein in Agrobacterium tumefaciens. Shown is TraR bound to its autoinducer 3-oxooctanoyl-homoserine lactone (OOHL) [3], also called Agrobacterium autoinducer (AAI) [4], and its target DNA. | TraR is a quorum sensing protein in Agrobacterium tumefaciens. Shown is TraR bound to its autoinducer 3-oxooctanoyl-homoserine lactone (OOHL) [3], also called Agrobacterium autoinducer (AAI) [4], and its target DNA. | ||
Quorum sensing is used by bacteria to regulate gene expression depending on cell-population density [1]. Therefore, Bacteria use small hormone-like proteins called autoinducers [2]. These autoinducers increase in concentration in connection to increasing cell density [1]. Reaching a minimal threshold stimulatory concentration, the autoinducers activate gene regulation processes [1]. This quorum sensing becomes beneficial as soon as it is performed by many cells [2]. Quorum sensing is used by Gram-negative as well as Gram-positive bacteria and occurs within and between bacterial species [1]. The communication via quorum sensing may have been a first step of multi-cellularity and makes the distinction between eukaryotes and prokaryotes more complex [1,2]. | Quorum sensing is used by bacteria to regulate gene expression depending on cell-population density [1]. Therefore, Bacteria use small hormone-like proteins called autoinducers [2]. These autoinducers increase in concentration in connection to increasing cell density [1]. Reaching a minimal threshold stimulatory concentration, the autoinducers activate gene regulation processes [1]. This quorum sensing becomes beneficial as soon as it is performed by many cells [2]. Quorum sensing is used by Gram-negative as well as Gram-positive bacteria and occurs within and between bacterial species [1]. The communication via quorum sensing may have been a first step of multi-cellularity and makes the distinction between eukaryotes and prokaryotes more complex [1,2]. | ||
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TraR is member of the quorum-sensing transcription factor family called LuxR including the Helix-Turn-Helix motif, that is typical for transcription factors (?) [5]. In presence of its autoinducer AAI, TraR regulates genes connected to the tumor inducing (Ti) plasmid [3]. When a certain cell density of Agrobacterium tumefaciens is reached, the transfer of the Ti-plasmid is induced. [5] There are two proteins that influence this transfer: TraR and TraI. The TraI gene encodes AAI. The absence of AAI causes rapid proteolysis of TraR [3], which implies, that AAI protects TraR from degradation [4]. TraR itself activates … | TraR is member of the quorum-sensing transcription factor family called LuxR including the Helix-Turn-Helix motif, that is typical for transcription factors (?) [5]. In presence of its autoinducer AAI, TraR regulates genes connected to the tumor inducing (Ti) plasmid [3]. When a certain cell density of Agrobacterium tumefaciens is reached, the transfer of the Ti-plasmid is induced. [5] There are two proteins that influence this transfer: TraR and TraI. The TraI gene encodes AAI. The absence of AAI causes rapid proteolysis of TraR [3], which implies, that AAI protects TraR from degradation [4]. TraR itself activates … | ||
Revision as of 21:13, 7 January 2014
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Contents |
Description
Shown is bound to its autoinducer 3-oxooctanoyl-homoserine lactone (OOHL) [3] and .
TraR is a quorum sensing protein in Agrobacterium tumefaciens. Shown is TraR bound to its autoinducer 3-oxooctanoyl-homoserine lactone (OOHL) [3], also called Agrobacterium autoinducer (AAI) [4], and its target DNA.
Quorum sensing is used by bacteria to regulate gene expression depending on cell-population density [1]. Therefore, Bacteria use small hormone-like proteins called autoinducers [2]. These autoinducers increase in concentration in connection to increasing cell density [1]. Reaching a minimal threshold stimulatory concentration, the autoinducers activate gene regulation processes [1]. This quorum sensing becomes beneficial as soon as it is performed by many cells [2]. Quorum sensing is used by Gram-negative as well as Gram-positive bacteria and occurs within and between bacterial species [1]. The communication via quorum sensing may have been a first step of multi-cellularity and makes the distinction between eukaryotes and prokaryotes more complex [1,2].
TraR is member of the quorum-sensing transcription factor family called LuxR including the Helix-Turn-Helix motif, that is typical for transcription factors (?) [5]. In presence of its autoinducer AAI, TraR regulates genes connected to the tumor inducing (Ti) plasmid [3]. When a certain cell density of Agrobacterium tumefaciens is reached, the transfer of the Ti-plasmid is induced. [5] There are two proteins that influence this transfer: TraR and TraI. The TraI gene encodes AAI. The absence of AAI causes rapid proteolysis of TraR [3], which implies, that AAI protects TraR from degradation [4]. TraR itself activates …
Structure
N-ter Region : Ligand binding secondary: N-ter dimer: linker: Dimer:
Ligand: Ligand Binding Site: neg charge dna binding
