4gwt

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{{STRUCTURE_4gwt| PDB=4gwt | SCENE= }}
{{STRUCTURE_4gwt| PDB=4gwt | SCENE= }}
===Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid===
===Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid===
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{{ABSTRACT_PUBMED_24311591}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024311591</ref><references group="xtra"/><references/>
[[Category: Peptidylprolyl isomerase]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Forest, K T.]]
[[Category: Forest, K T.]]

Revision as of 08:25, 8 January 2014

Template:STRUCTURE 4gwt

Contents

Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid

Template:ABSTRACT PUBMED 24311591

Function

[PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.[1] [2] [3]

About this Structure

4gwt is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Mortenson DE, Kreitler DF, Yun HG, Gellman SH, Forest KT. Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain. Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2506-12. doi:, 10.1107/S090744491302444X. Epub 2013 Nov 19. PMID:24311591 doi:http://dx.doi.org/10.1107/S090744491302444X
  1. ↑ Dougherty MK, Muller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK. Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell. 2005 Jan 21;17(2):215-24. PMID:15664191 doi:10.1016/j.molcel.2004.11.055
  2. ↑ Yu L, Mohamed AJ, Vargas L, Berglof A, Finn G, Lu KP, Smith CI. Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1. J Biol Chem. 2006 Jun 30;281(26):18201-7. Epub 2006 Apr 27. PMID:16644721 doi:10.1074/jbc.M603090200
  3. ↑ Lee TH, Chen CH, Suizu F, Huang P, Schiene-Fischer C, Daum S, Zhang YJ, Goate A, Chen RH, Zhou XZ, Lu KP. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. Mol Cell. 2011 Apr 22;42(2):147-59. doi: 10.1016/j.molcel.2011.03.005. Epub 2011 , Apr 14. PMID:21497122 doi:10.1016/j.molcel.2011.03.005

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