2vir
From Proteopedia
(New page: 200px<br /> <applet load="2vir" size="450" color="white" frame="true" align="right" spinBox="true" caption="2vir, resolution 3.25Å" /> '''INFLUENZA VIRUS HEM...) |
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| - | [[Image:2vir.gif|left|200px]]<br /> | + | [[Image:2vir.gif|left|200px]]<br /><applet load="2vir" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2vir" size=" | + | |
caption="2vir, resolution 3.25Å" /> | caption="2vir, resolution 3.25Å" /> | ||
'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY'''<br /> | '''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of the hemagglutinin (HA) of a mutant influenza virus that | + | The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies. |
==About this Structure== | ==About this Structure== | ||
| - | 2VIR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. This structure | + | 2VIR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. This structure supersedes the now removed PDB entry 1VIR. The following page contains interesting information on the relation of 2VIR with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Gigant, B.]] | [[Category: Gigant, B.]] | ||
[[Category: Knossow, M.]] | [[Category: Knossow, M.]] | ||
| - | [[Category: Skehel, J | + | [[Category: Skehel, J J.]] |
| - | [[Category: Wharton, S | + | [[Category: Wharton, S A.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: complex (hemagglutinin/immmunoglobulin)]] | [[Category: complex (hemagglutinin/immmunoglobulin)]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:56:13 2008'' |
Revision as of 16:56, 21 February 2008
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INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY
Overview
The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.
About this Structure
2VIR is a Protein complex structure of sequences from Mus musculus and Unidentified influenza virus with as ligand. This structure supersedes the now removed PDB entry 1VIR. The following page contains interesting information on the relation of 2VIR with [Hemagglutinin]. Full crystallographic information is available from OCA.
Reference
Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077
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