4c4d

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'''Unreleased structure'''
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{{STRUCTURE_4c4d| PDB=4c4d | SCENE= }}
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===Covalent glycosyl-enzyme intermediate of Hypocrea jecorina Cel7a E217Q mutant trapped using DNP-2-deoxy-2-fluoro-cellotrioside===
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{{ABSTRACT_PUBMED_24341799}}
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The entry 4c4d is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/GUX1_HYPJE GUX1_HYPJE]] The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
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Authors: Haddad-Momeni, M., Mackenzie, L., Sandgren, M., Withers, S.G., Stahlberg, J.
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==About this Structure==
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[[4c4d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C4D OCA].
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Description: Covalent glycosyl-enzyme intermediate of Hypocrea jecorina Cel7a E217Q mutant trapped using DNP-2-deoxy-2-fluoro-cellotrioside
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==Reference==
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<ref group="xtra">PMID:024341799</ref><references group="xtra"/><references/>
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[[Category: Haddad-Momeni, M.]]
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[[Category: Mackenzie, L.]]
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[[Category: Sandgren, M.]]
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[[Category: Stahlberg, J.]]
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[[Category: Withers, S G.]]
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[[Category: Cellobiohydrolase]]
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[[Category: Cellulase.]]
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[[Category: Glycoside hydrolase]]
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[[Category: Hydrolase]]

Revision as of 10:32, 8 January 2014

Template:STRUCTURE 4c4d

Contents

Covalent glycosyl-enzyme intermediate of Hypocrea jecorina Cel7a E217Q mutant trapped using DNP-2-deoxy-2-fluoro-cellotrioside

Template:ABSTRACT PUBMED 24341799

Function

[GUX1_HYPJE] The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.

About this Structure

4c4d is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Knott BC, Haddad Momeni M, Crowley MF, Mackenzie LF, Gotz AW, Sandgren M, Withers SG, Stahlberg J, Beckham GT. The Mechanism of Cellulose Hydrolysis by a Two-Step, Retaining Cellobiohydrolase Elucidated by Structural and Transition Path Sampling Studies. J Am Chem Soc. 2013 Dec 16. PMID:24341799 doi:http://dx.doi.org/10.1021/ja410291u

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OCA

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