4lnq

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'''Unreleased structure'''
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{{STRUCTURE_4lnq| PDB=4lnq | SCENE= }}
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===Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA===
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The entry 4lnq is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>
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Authors: Li, H., Wang, Z.-X., Wu, J.-W.
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==About this Structure==
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[[4lnq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LNQ OCA].
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Description: Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Li, H.]]
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[[Category: Wang, Z X.]]
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[[Category: Wu, J W.]]
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[[Category: Dna binding]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Ob fold]]

Revision as of 10:38, 8 January 2014

Template:STRUCTURE 4lnq

Contents

Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA

Function

[IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.[1] [2]

About this Structure

4lnq is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Xin H, D'Souza S, Jorgensen TN, Vaughan AT, Lengyel P, Kotzin BL, Choubey D. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol. 2006 May 15;176(10):5863-70. PMID:16670293
  2. ↑ Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009 Feb 20;323(5917):1057-60. doi: 10.1126/science.1169841. Epub 2009, Jan 8. PMID:19131592 doi:10.1126/science.1169841

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