4muw
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4muw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4muw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUW OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024102193</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024102193</ref><references group="xtra"/><references/> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Chmait, S.]] | [[Category: Chmait, S.]] | ||
[[Category: Jordan, S.]] | [[Category: Jordan, S.]] | ||
Revision as of 06:42, 15 January 2014
Contents |
Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor
Template:ABSTRACT PUBMED 24102193
Function
[PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]
About this Structure
4muw is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Hu E, Kunz RK, Chen N, Rumfelt S, Siegmund A, Andrews K, Chmait S, Zhao S, Davis C, Chen H, Lester-Zeiner D, Ma J, Biorn C, Shi J, Porter A, Treanor J, Allen JR. Design, Optimization, and Biological Evaluation of Novel Keto-Benzimidazoles as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A). J Med Chem. 2013 Oct 8. PMID:24102193 doi:http://dx.doi.org/10.1021/jm401234w
