3b0o
From Proteopedia
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{{STRUCTURE_3b0o| PDB=3b0o | SCENE= }} | {{STRUCTURE_3b0o| PDB=3b0o | SCENE= }} | ||
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===Crystal structure of alpha-lactalbumin=== | ===Crystal structure of alpha-lactalbumin=== | ||
| + | {{ABSTRACT_PUBMED_23155056}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/LALBA_HUMAN LALBA_HUMAN]] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3b0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3b0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0O OCA]. |
| - | [[Category: | + | |
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023155056</ref><references group="xtra"/><references/> | ||
| + | [[Category: Human]] | ||
[[Category: Kuwajima, K.]] | [[Category: Kuwajima, K.]] | ||
[[Category: Makabe, K.]] | [[Category: Makabe, K.]] | ||
[[Category: Calcium binding protein]] | [[Category: Calcium binding protein]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
Revision as of 06:46, 15 January 2014
Contents |
Crystal structure of alpha-lactalbumin
Template:ABSTRACT PUBMED 23155056
Function
[LALBA_HUMAN] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
About this Structure
3b0o is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Makabe K, Nakamura T, Kuwajima K. Structural insights into the stability perturbations induced by N-terminal variation in human and goat alpha-lactalbumin. Protein Eng Des Sel. 2013 Feb;26(2):165-70. doi: 10.1093/protein/gzs093. Epub, 2012 Nov 14. PMID:23155056 doi:http://dx.doi.org/10.1093/protein/gzs093
