4ly9
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4ly9| PDB=4ly9 | SCENE= }} | {{STRUCTURE_4ly9| PDB=4ly9 | SCENE= }} | ||
===Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate=== | ===Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate=== | ||
| + | {{ABSTRACT_PUBMED_24226772}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4ly9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LY9 OCA]. | + | [[4ly9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LY9 OCA]. |
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024226772</ref><references group="xtra"/><references/> | ||
| + | [[Category: Human]] | ||
[[Category: Jordan, S R.]] | [[Category: Jordan, S R.]] | ||
[[Category: Carbohydrate binding protein]] | [[Category: Carbohydrate binding protein]] | ||
Revision as of 06:52, 15 January 2014
Contents |
Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate
Template:ABSTRACT PUBMED 24226772
Function
[GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme.
About this Structure
4ly9 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Lloyd DJ, St Jean DJ Jr, Kurzeja RJ, Wahl RC, Michelsen K, Cupples R, Chen M, Wu J, Sivits G, Helmering J, Komorowski R, Ashton KS, Pennington LD, Fotsch C, Vazir M, Chen K, Chmait S, Zhang J, Liu L, Norman MH, Andrews KL, Bartberger MD, Van G, Galbreath EJ, Vonderfecht SL, Wang M, Jordan SR, Veniant MM, Hale C. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40. doi: 10.1038/nature12724. Epub 2013 Nov 13. PMID:24226772 doi:http://dx.doi.org/10.1038/nature12724
