4myq

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{{STRUCTURE_4myq| PDB=4myq | SCENE= }}
{{STRUCTURE_4myq| PDB=4myq | SCENE= }}
===Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33===
===Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33===
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{{ABSTRACT_PUBMED_24361374}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024361374</ref><references group="xtra"/><references/>
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Edwards, T E.]]
[[Category: Edwards, T E.]]

Revision as of 06:55, 15 January 2014

Template:STRUCTURE 4myq

Contents

Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33

Template:ABSTRACT PUBMED 24361374

Function

[PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.[1] [2]

About this Structure

4myq is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT. Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity. Science. 2000 Jun 9;288(5472):1822-5. PMID:10846163
  2. Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT. Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J Mol Biol. 2004 Mar 19;337(2):355-65. PMID:15003452 doi:http://dx.doi.org/10.1016/j.jmb.2004.01.040

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