3rq4
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:3rq4.png|left|200px]] | ||
| - | |||
{{STRUCTURE_3rq4| PDB=3rq4 | SCENE= }} | {{STRUCTURE_3rq4| PDB=3rq4 | SCENE= }} | ||
| - | |||
===Crystal structure of suppressor of variegation 4-20 homolog 2=== | ===Crystal structure of suppressor of variegation 4-20 homolog 2=== | ||
| + | {{ABSTRACT_PUBMED_24396869}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/SV422_HUMAN SV422_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3rq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3rq4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQ4 OCA]. |
==See Also== | ==See Also== | ||
*[[Histone methyltransferase|Histone methyltransferase]] | *[[Histone methyltransferase|Histone methyltransferase]] | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024396869</ref><references group="xtra"/><references/> | ||
[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
[[Category: Bountra, C.]] | [[Category: Bountra, C.]] | ||
Revision as of 07:02, 15 January 2014
Contents |
Crystal structure of suppressor of variegation 4-20 homolog 2
Template:ABSTRACT PUBMED 24396869
Function
[SV422_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).
About this Structure
3rq4 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J. Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. FEBS Lett. 2013 Nov 29;587(23):3859-68. PMID:24396869
Categories: Histone-lysine N-methyltransferase | Human | Arrowsmith, C H. | Bountra, C. | Dong, A. | Edwards, A M. | Loppnau, P. | Min, J. | SGC, Structural Genomics Consortium. | Tempel, W. | Weigelt, J. | Wu, H. | Zeng, H. | Sgc | Structural genomic | Structural genomics consortium | Suppressor | Suv420h2 | Transferase | Variegation 4-20 homolog 2
