4bup
From Proteopedia
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===A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases=== | ===A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases=== | ||
{{ABSTRACT_PUBMED_24049080}} | {{ABSTRACT_PUBMED_24049080}} | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/SV421_MOUSE SV421_MOUSE]] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).<ref>PMID:15145825</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4bup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4bup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUP OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024049080</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024049080</ref><references group="xtra"/><references/> | ||
[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
| - | [[Category: | + | [[Category: Lk3 transgenic mice]] |
[[Category: Cronin, N B.]] | [[Category: Cronin, N B.]] | ||
[[Category: Southall, S M.]] | [[Category: Southall, S M.]] | ||
Revision as of 07:09, 15 January 2014
Contents |
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases
Template:ABSTRACT PUBMED 24049080
Function
[SV421_MOUSE] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).[1]
About this Structure
4bup is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
Reference
- Southall SM, Cronin NB, Wilson JR. A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases. Nucleic Acids Res. 2013 Sep 18. PMID:24049080 doi:10.1093/nar/gkt776
- ↑ Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1;18(11):1251-62. Epub 2004 May 14. PMID:15145825 doi:http://dx.doi.org/10.1101/gad.300704
