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3zgg

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_3zgg| PDB=3zgg | SCENE= }}
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===Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with NPE caged UDP-Gal (C222(1) space group)===
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{{ABSTRACT_PUBMED_18275942}}
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The entry 3zgg is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
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Authors: Jorgensen, R., Batot, G.O., Hindsgaul, O., Tanaka, H., Perez, S., Imberty, A., Breton, C., Royant, A., Palcic, M.M.
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==About this Structure==
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[[3zgg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGG OCA].
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Description: Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with in complex with NPE caged UDP-Gal (C222(1) space group)
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==Reference==
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<ref group="xtra">PMID:018275942</ref><references group="xtra"/><references/>
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[[Category: Batot, G O.]]
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[[Category: Breton, C.]]
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[[Category: Hindsgaul, O.]]
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[[Category: Imberty, A.]]
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[[Category: Jorgensen, R.]]
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[[Category: Palcic, M M.]]
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[[Category: Perez, S.]]
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[[Category: Royant, A.]]
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[[Category: Tanaka, H.]]
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[[Category: Catalytic domain]]
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[[Category: Glycosyltransferase]]
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[[Category: Transferase]]

Revision as of 08:10, 15 January 2014

Template:STRUCTURE 3zgg

Contents

Crystal structure of the Fucosylgalactoside alpha N- acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with NPE caged UDP-Gal (C222(1) space group)

Template:ABSTRACT PUBMED 18275942

Function

[BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.

About this Structure

3zgg is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Mannerstedt K, Hindsgaul O. Synthesis and photolytic activation of 6-O-2-nitrobenzyl uridine-5'-diphosphogalactose: a 'caged' UDP-Gal derivative. Carbohydr Res. 2008 Apr 7;343(5):875-81. doi: 10.1016/j.carres.2008.01.021. Epub , 2008 Jan 26. PMID:18275942 doi:http://dx.doi.org/10.1016/j.carres.2008.01.021

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OCA

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