4n06

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m (Protected "4n06" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4n06| PDB=4n06 | SCENE= }}
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===Crystal structure of Cas1 from Archaeoglobus fulgidus and its nucleolytic activity===
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{{ABSTRACT_PUBMED_24211577}}
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The entry 4n06 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CAS1A_ARCFU CAS1A_ARCFU]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity).
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Authors: Kim, T.Y., Shin, M., Yen, L.H.T., Kim, J.S.
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==About this Structure==
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[[4n06]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N06 OCA].
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Description: Crystal structure of Cas1 from Archaeoglobus fulgidus and its nucleolytic activity
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==Reference==
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<ref group="xtra">PMID:024211577</ref><references group="xtra"/><references/>
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[[Category: Archaeoglobus fulgidus]]
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[[Category: Kim, J S.]]
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[[Category: Kim, T Y.]]
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[[Category: Shin, M.]]
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[[Category: Yen, L H.T.]]
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[[Category: Hydrolase]]

Revision as of 08:12, 15 January 2014

Template:STRUCTURE 4n06

Contents

Crystal structure of Cas1 from Archaeoglobus fulgidus and its nucleolytic activity

Template:ABSTRACT PUBMED 24211577

Function

[CAS1A_ARCFU] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity).

About this Structure

4n06 is a 2 chain structure with sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

  • Kim TY, Shin M, Huynh Thi Yen L, Kim JS. Crystal structure of Cas1 from Archaeoglobus fulgidus and characterization of its nucleolytic activity. Biochem Biophys Res Commun. 2013 Nov 29;441(4):720-5. doi:, 10.1016/j.bbrc.2013.10.122. Epub 2013 Nov 5. PMID:24211577 doi:http://dx.doi.org/10.1016/j.bbrc.2013.10.122

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OCA

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