2bkh
From Proteopedia
| Line 31: | Line 31: | ||
[[Category: reverse myosin]] | [[Category: reverse myosin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:40:35 2007'' |
Revision as of 14:35, 30 October 2007
|
MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2) CRYSTAL STRUCTURE
Overview
Here we solve a 2.4-A structure of a truncated version of the, reverse-direction myosin motor, myosin VI, that contains the motor domain, and binding sites for two calmodulin molecules. The structure reveals only, minor differences in the motor domain from that in plus-end directed, myosins, with the exception of two unique inserts. The first is near the, nucleotide-binding pocket and alters the rates of nucleotide association, and dissociation. The second unique insert forms an integral part of the, myosin VI converter domain along with a calmodulin bound to a novel target, motif within the insert. This serves to redirect the effective 'lever arm', of myosin VI, which includes a second calmodulin bound to an 'IQ motif', towards the pointed (minus) end of the actin filament. This ... [(full description)]
About this Structure
2BKH is a [Protein complex] structure of sequences from [Drosophila melanogaster] and [Sus scrofa] with CA and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The structure of the myosin VI motor reveals the mechanism of directionality reversal., Menetrey J, Bahloul A, Wells AL, Yengo CM, Morris CA, Sweeney HL, Houdusse A, Nature. 2005 Jun 9;435(7043):779-85. PMID:15944696
Page seeded by OCA on Tue Oct 30 16:40:35 2007
