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4l9c

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4l9c| PDB=4l9c | SCENE= }}
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===Crystal structure of the FP domain of human F-box protein Fbxo7 (native)===
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The entry 4l9c is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN]] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Du,Z., Huang,X., Shang,J., Yang,Y., Wang,G.
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==Function==
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[[http://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN]] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.<ref>PMID:15145941</ref> <ref>PMID:16510124</ref>
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Description: Crystal structure of the FP domain of human F-box protein Fbxo7 (native)
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==About this Structure==
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[[4l9c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9C OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Du,Z.]]
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[[Category: Huang,X.]]
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[[Category: Shang,J.]]
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[[Category: Wang,G.]]
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[[Category: Yang,Y.]]
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[[Category: Alpha/beta fold]]
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[[Category: Protein binding]]

Revision as of 08:24, 15 January 2014

Template:STRUCTURE 4l9c

Contents

Crystal structure of the FP domain of human F-box protein Fbxo7 (native)

Disease

[FBX7_HUMAN] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

[FBX7_HUMAN] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.[1] [2]

About this Structure

4l9c is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Hsu JM, Lee YC, Yu CT, Huang CY. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. J Biol Chem. 2004 Jul 30;279(31):32592-602. Epub 2004 May 15. PMID:15145941 doi:http://dx.doi.org/10.1074/jbc.M404950200
  2. ↑ Chang YF, Cheng CM, Chang LK, Jong YJ, Yuo CY. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1022-6. Epub 2006 Feb 21. PMID:16510124 doi:http://dx.doi.org/10.1016/j.bbrc.2006.02.061

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