4nj4

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'''Unreleased structure'''
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{{STRUCTURE_4nj4| PDB=4nj4 | SCENE= }}
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===Crystal Structure of Human ALKBH5===
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The entry 4nj4 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ALKB5_HUMAN ALKB5_HUMAN]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.<ref>PMID:21264265</ref> <ref>PMID:23177736</ref>
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Authors: Aik, W.S., McDonough, M.A., Schofield, C.J.
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==About this Structure==
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[[4nj4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJ4 OCA].
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Description: Crystal Structure of An Oxygenase In Complex with An Inhibitor
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Aik, W S.]]
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[[Category: McDonough, M A.]]
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[[Category: Schofield, C J.]]
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[[Category: Dioxygenase]]
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[[Category: Double-stranded beta helix]]
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[[Category: Jelly-roll motif]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Rna]]
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[[Category: Rna demethylase]]

Revision as of 08:27, 15 January 2014

Template:STRUCTURE 4nj4

Contents

Crystal Structure of Human ALKBH5

Function

[ALKB5_HUMAN] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.[1] [2]

About this Structure

4nj4 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schodel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1alpha (HIF-1alpha). PLoS One. 2011 Jan 14;6(1):e16210. doi: 10.1371/journal.pone.0016210. PMID:21264265 doi:http://dx.doi.org/10.1371/journal.pone.0016210
  2. ↑ Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vagbo CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013 Jan 10;49(1):18-29. doi: 10.1016/j.molcel.2012.10.015. Epub 2012, Nov 21. PMID:23177736 doi:http://dx.doi.org/10.1016/j.molcel.2012.10.015

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