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4o2w

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'''Unreleased structure'''
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{{STRUCTURE_4o2w| PDB=4o2w | SCENE= }}
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===Crystal structure of the third RCC1-like domain of HERC1===
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The entry 4o2w is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN]] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref>
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Authors: Dong, A., Hu, J., Li, Y., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4o2w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O2W OCA].
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Description: Crystal structure of the third RCC1-like domain of HERC1
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Dong, A.]]
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[[Category: Edwards, A M.]]
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[[Category: Hu, J.]]
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[[Category: Li, Y.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tong, Y.]]
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[[Category: Walker, J R.]]
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[[Category: Beta-propeller]]
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[[Category: Herc1]]
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[[Category: Ligase]]
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[[Category: Rcc1]]
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[[Category: Rld]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]

Revision as of 08:28, 15 January 2014

Template:STRUCTURE 4o2w

Contents

Crystal structure of the third RCC1-like domain of HERC1

Function

[HERC1_HUMAN] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.[1] [2] [3]

About this Structure

4o2w is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaro S, Barbacid M. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. EMBO J. 1996 Aug 15;15(16):4262-73. PMID:8861955
  2. ↑ Rosa JL, Barbacid M. A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70. Oncogene. 1997 Jul 3;15(1):1-6. PMID:9233772 doi:http://dx.doi.org/10.1038/sj.onc.1201170
  3. ↑ Garcia-Gonzalo FR, Bartrons R, Ventura F, Rosa JL. Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins. FEBS Lett. 2005 Jan 17;579(2):343-8. PMID:15642342 doi:http://dx.doi.org/S0014-5793(04)01504-2

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