1gtw
From Proteopedia
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| - | [[Image:1gtw.png|left|200px]] | ||
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{{STRUCTURE_1gtw| PDB=1gtw | SCENE= }} | {{STRUCTURE_1gtw| PDB=1gtw | SCENE= }} | ||
| + | ===crystal structure of C/EBPbeta bZip homodimer bound to a DNA fragment from the tom-1A promoter=== | ||
| + | {{ABSTRACT_PUBMED_11792321}} | ||
| - | == | + | ==Function== |
| - | + | [[http://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN]] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | [[1gtw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[1gtw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTW OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:011792321</ref><references group="xtra"/> | + | <ref group="xtra">PMID:011792321</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Ogata, K.]] | [[Category: Ogata, K.]] | ||
[[Category: Tahirov, T H.]] | [[Category: Tahirov, T H.]] | ||
| - | [[Category: Bzip]] | ||
[[Category: C/ebp]] | [[Category: C/ebp]] | ||
| - | [[Category: | + | [[Category: Hypothetical protein]] |
[[Category: Protein-dna complex]] | [[Category: Protein-dna complex]] | ||
[[Category: Transcription factor]] | [[Category: Transcription factor]] | ||
[[Category: Transcription-dna complex]] | [[Category: Transcription-dna complex]] | ||
[[Category: Transcription/dna]] | [[Category: Transcription/dna]] | ||
Revision as of 05:53, 22 January 2014
Contents |
crystal structure of C/EBPbeta bZip homodimer bound to a DNA fragment from the tom-1A promoter
Template:ABSTRACT PUBMED 11792321
Function
[CEBPB_HUMAN] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).[1]
About this Structure
1gtw is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S, Ogata K. Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. Cell. 2002 Jan 11;108(1):57-70. PMID:11792321
- ↑ Park SH, Choi HJ, Yang H, Do KH, Kim J, Lee DW, Moon Y. Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. J Biol Chem. 2010 Nov 12;285(46):35330-9. doi: 10.1074/jbc.M110.136259. Epub 2010, Sep 9. PMID:20829347 doi:10.1074/jbc.M110.136259
