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4k6m
From Proteopedia
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{{STRUCTURE_4k6m| PDB=4k6m | SCENE= }} | {{STRUCTURE_4k6m| PDB=4k6m | SCENE= }} | ||
===Crystal Structure of the full-length Japanese encephalitis virus NS5=== | ===Crystal Structure of the full-length Japanese encephalitis virus NS5=== | ||
| + | {{ABSTRACT_PUBMED_23950717}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4k6m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4k6m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Japanese_encephalitis Japanese encephalitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6M OCA]. |
| - | [[Category: Japanese encephalitis | + | |
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023950717</ref><references group="xtra"/><references/> | ||
| + | [[Category: Japanese encephalitis]] | ||
[[Category: Gong, P.]] | [[Category: Gong, P.]] | ||
[[Category: Lu, G.]] | [[Category: Lu, G.]] | ||
Revision as of 06:01, 22 January 2014
Contents |
Crystal Structure of the full-length Japanese encephalitis virus NS5
Template:ABSTRACT PUBMED 23950717
Function
[Q5NT71_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]
About this Structure
4k6m is a 2 chain structure with sequence from Japanese encephalitis. Full crystallographic information is available from OCA.
Reference
- Lu G, Gong P. Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface. PLoS Pathog. 2013;9(8):e1003549. doi: 10.1371/journal.ppat.1003549. Epub 2013 Aug, 8. PMID:23950717 doi:http://dx.doi.org/10.1371/journal.ppat.1003549
