3au5
From Proteopedia
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{{STRUCTURE_3au5| PDB=3au5 | SCENE= }} | {{STRUCTURE_3au5| PDB=3au5 | SCENE= }} | ||
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===Structure of the human myosin-X MyTH4-FERM cassette=== | ===Structure of the human myosin-X MyTH4-FERM cassette=== | ||
| + | {{ABSTRACT_PUBMED_21642953}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3au5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3au5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AU5 OCA]. |
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021642953</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021642953</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Hakoshima, T.]] | [[Category: Hakoshima, T.]] | ||
[[Category: Hirano, Y.]] | [[Category: Hirano, Y.]] | ||
Revision as of 06:19, 22 January 2014
Contents |
Structure of the human myosin-X MyTH4-FERM cassette
Template:ABSTRACT PUBMED 21642953
Function
[MYO10_HUMAN] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).[1]
About this Structure
3au5 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- Hirano Y, Hatano T, Takahashi A, Toriyama M, Inagaki N, Hakoshima T. Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain. EMBO J. 2011 Jun 3;30(13):2734-47. doi: 10.1038/emboj.2011.177. PMID:21642953 doi:10.1038/emboj.2011.177
- ↑ Bohil AB, Robertson BW, Cheney RE. Myosin-X is a molecular motor that functions in filopodia formation. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12411-6. Epub 2006 Aug 7. PMID:16894163 doi:10.1073/pnas.0602443103
