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3a28

From Proteopedia

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[[Image:3a28.png|left|200px]]
 
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{{STRUCTURE_3a28| PDB=3a28 | SCENE= }}
{{STRUCTURE_3a28| PDB=3a28 | SCENE= }}
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===Crystal structure of L-2,3-butanediol dehydrogenase===
===Crystal structure of L-2,3-butanediol dehydrogenase===
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{{ABSTRACT_PUBMED_19941855}}
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{{ABSTRACT_PUBMED_19941855}}
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==Function==
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[[http://www.uniprot.org/uniprot/BUDC_CORGT BUDC_CORGT]] Catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol (L-BD) in the presence of NADH. To a lesser extent, can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD, D-BD, 2-butanol, 1,2-propanediol, ethanol, acetol, 1,2-butanediol, 1,3-butanediol, n-butanol, and n-propanol. Cannot reduce (R)-acetoin, acetol, dihydroxyacetone and 2,4-pentanedione.[REFERENCE:1]<ref>PMID:11577733</ref>
==About this Structure==
==About this Structure==
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[[3a28]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A28 OCA].
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[[3a28]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A28 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:019941855</ref><references group="xtra"/>
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<ref group="xtra">PMID:019941855</ref><references group="xtra"/><references/>
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[[Category: Corynebacterium glutamicum]]
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[[Category: Micrococcus glutamicus kinoshita et al. 1958]]
[[Category: Kurisu, G.]]
[[Category: Kurisu, G.]]
[[Category: Kusunoki, M.]]
[[Category: Kusunoki, M.]]

Revision as of 06:22, 22 January 2014

Template:STRUCTURE 3a28

Contents

Crystal structure of L-2,3-butanediol dehydrogenase

Template:ABSTRACT PUBMED 19941855

Function

[BUDC_CORGT] Catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol (L-BD) in the presence of NADH. To a lesser extent, can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD, D-BD, 2-butanol, 1,2-propanediol, ethanol, acetol, 1,2-butanediol, 1,3-butanediol, n-butanol, and n-propanol. Cannot reduce (R)-acetoin, acetol, dihydroxyacetone and 2,4-pentanedione.[REFERENCE:1][1]

About this Structure

3a28 is a 8 chain structure with sequence from "micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958. Full crystallographic information is available from OCA.

Reference

  • Otagiri M, Ui S, Takusagawa Y, Ohtsuki T, Kurisu G, Kusunoki M. Structural basis for chiral substrate recognition by two 2,3-butanediol dehydrogenases. FEBS Lett. 2010 Jan 4;584(1):219-23. Epub . PMID:19941855 doi:10.1016/j.febslet.2009.11.068
  1. ↑ Takusagawa Y, Otagiri M, Ui S, Ohtsuki T, Mimura A, Ohkuma M, Kudo T. Purification and characterization of L-2,3-butanediol dehydrogenase of Brevibacterium saccharolyticum C-1012 expressed in Escherichia coli. Biosci Biotechnol Biochem. 2001 Aug;65(8):1876-8. PMID:11577733

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