4mr6
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[4mr6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR6 OCA]. | + | [[4mr6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR6 OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024248379</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024248379</ref><references group="xtra"/><references/> | ||
| + | [[Category: Human]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
[[Category: Bountra, C.]] | [[Category: Bountra, C.]] | ||
Revision as of 06:23, 22 January 2014
Contents |
Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-208)
Template:ABSTRACT PUBMED 24248379
Function
[BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.[1]
About this Structure
4mr6 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Picaud S, Wells C, Felletar I, Brotherton D, Martin S, Savitsky P, Diez-Dacal B, Philpott M, Bountra C, Lingard H, Fedorov O, Muller S, Brennan PE, Knapp S, Filippakopoulos P. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc Natl Acad Sci U S A. 2013 Nov 18. PMID:24248379 doi:http://dx.doi.org/10.1073/pnas.1310658110
- ↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018
Categories: Human | Arrowsmith, C H. | Bountra, C. | Delft, F von. | Edwards, A M. | Fedorov, O. | Felletar, I. | Filippakopoulos, P. | Knapp, S. | Martin, S. | Picaud, S. | SGC, Structural Genomics Consortium. | Weigelt, J. | Brd2 | Inhibitor complex | Ring3 | Rvx-208 | Sgc | Small molecule inhibitor | Structural genomics consortium | Transcription-transcription inhibitor complex
