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4mr6

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==About this Structure==
==About this Structure==
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[[4mr6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR6 OCA].
+
[[4mr6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR6 OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024248379</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024248379</ref><references group="xtra"/><references/>
 +
[[Category: Human]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Bountra, C.]]

Revision as of 06:23, 22 January 2014

Template:STRUCTURE 4mr6

Contents

Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-208)

Template:ABSTRACT PUBMED 24248379

Function

[BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.[1]

About this Structure

4mr6 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Picaud S, Wells C, Felletar I, Brotherton D, Martin S, Savitsky P, Diez-Dacal B, Philpott M, Bountra C, Lingard H, Fedorov O, Muller S, Brennan PE, Knapp S, Filippakopoulos P. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc Natl Acad Sci U S A. 2013 Nov 18. PMID:24248379 doi:http://dx.doi.org/10.1073/pnas.1310658110
  1. ↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

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