4k34
From Proteopedia
(Difference between revisions)
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===Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation=== | ===Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation=== | ||
{{ABSTRACT_PUBMED_24099674}} | {{ABSTRACT_PUBMED_24099674}} | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CUSC_ECOLI CUSC_ECOLI]] Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis.<ref>PMID:11399769</ref> <ref>PMID:12813074</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4k34]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4k34]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K34 OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024099674</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024099674</ref><references group="xtra"/><references/> | ||
| - | [[Category: | + | [[Category: Ecoli]] |
[[Category: Su, C C.]] | [[Category: Su, C C.]] | ||
[[Category: Beta barrel]] | [[Category: Beta barrel]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
Revision as of 06:24, 22 January 2014
Contents |
Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation
Template:ABSTRACT PUBMED 24099674
Function
[CUSC_ECOLI] Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis.[1] [2]
About this Structure
4k34 is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.
Reference
- Lei HT, Bolla JR, Su CC, Yu EW. Crystal Structures of CusC Review Conformational Changes Accompanying Folding and Transmembrane Channel Formation. J Mol Biol. 2013 Oct 4. pii: S0022-2836(13)00626-8. doi:, 10.1016/j.jmb.2013.09.042. PMID:24099674 doi:http://dx.doi.org/10.1016/j.jmb.2013.09.042
- ↑ Outten FW, Huffman DL, Hale JA, O'Halloran TV. The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli. J Biol Chem. 2001 Aug 17;276(33):30670-7. Epub 2001 Jun 8. PMID:11399769 doi:http://dx.doi.org/10.1074/jbc.M104122200
- ↑ Franke S, Grass G, Rensing C, Nies DH. Molecular analysis of the copper-transporting efflux system CusCFBA of Escherichia coli. J Bacteriol. 2003 Jul;185(13):3804-12. PMID:12813074
