3a6m

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[[Image:3a6m.png|left|200px]]
 
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{{STRUCTURE_3a6m| PDB=3a6m | SCENE= }}
{{STRUCTURE_3a6m| PDB=3a6m | SCENE= }}
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===Crystal structure of GrpE from Thermus thermophilus HB8===
===Crystal structure of GrpE from Thermus thermophilus HB8===
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{{ABSTRACT_PUBMED_20036249}}
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{{ABSTRACT_PUBMED_20036249}}
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==Function==
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[[http://www.uniprot.org/uniprot/GRPE_THET8 GRPE_THET8]] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity).
==About this Structure==
==About this Structure==
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[[3a6m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A6M OCA].
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[[3a6m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A6M OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:020036249</ref><references group="xtra"/>
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<ref group="xtra">PMID:020036249</ref><references group="xtra"/><references/>
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[[Category: Thermus thermophilus]]
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[[Category: Thet8]]
[[Category: Miki, K.]]
[[Category: Miki, K.]]
[[Category: Nakamura, A.]]
[[Category: Nakamura, A.]]

Revision as of 06:29, 22 January 2014

Template:STRUCTURE 3a6m

Contents

Crystal structure of GrpE from Thermus thermophilus HB8

Template:ABSTRACT PUBMED 20036249

Function

[GRPE_THET8] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity).

About this Structure

3a6m is a 2 chain structure with sequence from Thet8. Full crystallographic information is available from OCA.

Reference

  • Nakamura A, Takumi K, Miki K. Crystal structure of a thermophilic GrpE protein: insight into thermosensing function for the DnaK chaperone system. J Mol Biol. 2010 Mar 5;396(4):1000-11. Epub 2009 Dec 28. PMID:20036249 doi:10.1016/j.jmb.2009.12.028

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