1r4o

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[[Image:1r4o.png|left|200px]]
 
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{{STRUCTURE_1r4o| PDB=1r4o | SCENE= }}
{{STRUCTURE_1r4o| PDB=1r4o | SCENE= }}
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===Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA===
===Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA===
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{{ABSTRACT_PUBMED_1865905}}
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{{ABSTRACT_PUBMED_1865905}}
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==Function==
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[[http://www.uniprot.org/uniprot/GCR_RAT GCR_RAT]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>
==About this Structure==
==About this Structure==
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[[1r4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4O OCA].
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[[1r4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4O OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:001865905</ref><references group="xtra"/>
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<ref group="xtra">PMID:001865905</ref><references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Buffalo rat]]
[[Category: Freedman, L P.]]
[[Category: Freedman, L P.]]
[[Category: Luisi, B F.]]
[[Category: Luisi, B F.]]

Revision as of 06:31, 22 January 2014

Template:STRUCTURE 1r4o

Contents

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

Template:ABSTRACT PUBMED 1865905

Function

[GCR_RAT] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).[1]

About this Structure

1r4o is a 4 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.

See Also

Reference

  • Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature. 1991 Aug 8;352(6335):497-505. PMID:1865905 doi:http://dx.doi.org/10.1038/352497a0
  1. ↑ Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK. BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. Mol Cell Biol. 2003 Sep;23(17):6210-20. PMID:12917342

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