2z9k
From Proteopedia
(New page: 200px<br /><applet load="2z9k" size="350" color="white" frame="true" align="right" spinBox="true" caption="2z9k, resolution 1.85Å" /> '''Complex structure of...) |
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==Overview== | ==Overview== | ||
| - | Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and | + | Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization. |
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454- | + | Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17981158 17981158] |
[[Category: Sars coronavirus]] | [[Category: Sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Lee, C | + | [[Category: Lee, C C.]] |
| - | [[Category: Wang, A | + | [[Category: Wang, A H.]] |
[[Category: DMS]] | [[Category: DMS]] | ||
[[Category: DOZ]] | [[Category: DOZ]] | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:00:55 2008'' |
Revision as of 17:00, 21 February 2008
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Complex structure of SARS-CoV 3C-like protease with JMF1600
Overview
Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.
About this Structure
2Z9K is a Single protein structure of sequence from Sars coronavirus with and as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:17981158
Page seeded by OCA on Thu Feb 21 19:00:55 2008
Categories: Sars coronavirus | Single protein | Lee, C C. | Wang, A H. | DMS | DOZ | Atp-binding | Complex | Cytoplasm | Endonuclease | Exonuclease | Helicase | Hydrolase | Membrane | Metal-binding | Nuclease | Nucleotide-binding | Nucleotidyltransferase | Protease | Ribosomal frameshift | Rna replication | Rna-binding | Rna-directed rna polymerase | Thiol protease | Transferase | Transmembrane | Zinc | Zinc-finger
