4nqw

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'''Unreleased structure'''
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{{STRUCTURE_4nqw| PDB=4nqw | SCENE= }}
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===Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA===
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The entry 4nqw is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/SIGK_MYCTU SIGK_MYCTU]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83. [[http://www.uniprot.org/uniprot/RSKA_MYCTU RSKA_MYCTU]] Represses SigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of SigK-regulated genes, such as mpt70 and mpt83.
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Authors: Shukla, J.K., Gopal, B.
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==About this Structure==
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[[4nqw]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vdo 3vdo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQW OCA].
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Description: Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA
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[[Category: Gopal, B.]]
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[[Category: Shukla, J K.]]
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[[Category: Anti-sigma factor]]
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[[Category: Dna binding]]
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[[Category: Dna binding protein-protein binding complex]]
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[[Category: Promoter dna binding and transcription initiation]]
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[[Category: Sigma factor]]
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[[Category: Transcription initiation]]

Revision as of 06:53, 22 January 2014

Template:STRUCTURE 4nqw

Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA

Function

[SIGK_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83. [RSKA_MYCTU] Represses SigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of SigK-regulated genes, such as mpt70 and mpt83.

About this Structure

4nqw is a 2 chain structure. This structure supersedes the now removed PDB entry 3vdo. Full crystallographic information is available from OCA.

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OCA

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