4mda

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'''Unreleased structure'''
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{{STRUCTURE_4mda| PDB=4mda | SCENE= }}
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===Structure of Mos1 transposase catalytic domain and Raltegravir with Mn===
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{{ABSTRACT_PUBMED_24397848}}
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The entry 4mda is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MOS1T_DROMA MOS1T_DROMA]] Mediates transposition of transposon Mos1 by a 'cut and paste' mechanism. Transposases are sequence-specific nucleases and strand transferases that catalyze transposition through an ordered series of events: sequence-specific binding of transposase to the terminal inverted repeats (IR) present at each end of the transposon, pairing of the transposon IRs in a paired-end complex (PEC), cleavage of one or both DNA strands at each transposon end, capture of target DNA, and strand transfer to insert the transposon at a new site.
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Authors: Richardson, J.M.
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==About this Structure==
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[[4mda]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MDA OCA].
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Description: Structure of Mos1 transposase catalytic domain and Raltegravir with Mn
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==Reference==
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<ref group="xtra">PMID:024397848</ref><references group="xtra"/><references/>
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[[Category: Richardson, J M.]]
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[[Category: Ddd motif]]
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[[Category: Dna integration]]
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[[Category: Dna transposition]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Recombinase]]
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[[Category: Rnase-h fold]]
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[[Category: Transposon dna]]

Revision as of 06:56, 22 January 2014

Template:STRUCTURE 4mda

Contents

Structure of Mos1 transposase catalytic domain and Raltegravir with Mn

Template:ABSTRACT PUBMED 24397848

Function

[MOS1T_DROMA] Mediates transposition of transposon Mos1 by a 'cut and paste' mechanism. Transposases are sequence-specific nucleases and strand transferases that catalyze transposition through an ordered series of events: sequence-specific binding of transposase to the terminal inverted repeats (IR) present at each end of the transposon, pairing of the transposon IRs in a paired-end complex (PEC), cleavage of one or both DNA strands at each transposon end, capture of target DNA, and strand transfer to insert the transposon at a new site.

About this Structure

4mda is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Wolkowicz UM, Morris ER, Robson M, Trubitsyna M, Richardson JM. Structural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug Raltegravir. ACS Chem Biol. 2014 Jan 10. PMID:24397848 doi:http://dx.doi.org/10.1021/cb400791u

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OCA

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