4nh9

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'''Unreleased structure'''
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{{STRUCTURE_4nh9| PDB=4nh9 | SCENE= }}
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===Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity===
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{{ABSTRACT_PUBMED_24332488}}
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The entry 4nh9 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/ENPL_HUMAN ENPL_HUMAN]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.<ref>PMID:18264092</ref>
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Authors: Zuccola, H.J., Ernst, J.T.
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==About this Structure==
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[[4nh9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NH9 OCA].
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Description: Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
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==Reference==
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<ref group="xtra">PMID:024332488</ref><references group="xtra"/><references/>
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[[Category: Ernst, J T.]]
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[[Category: Zuccola, H J.]]
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[[Category: A/b structure]]
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[[Category: Chaperone]]
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[[Category: Endoplasmic reticulum]]

Revision as of 06:58, 22 January 2014

Template:STRUCTURE 4nh9

Contents

Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity

Template:ABSTRACT PUBMED 24332488

Function

[ENPL_HUMAN] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.[1]

About this Structure

4nh9 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Ernst JT, Liu M, Zuccola H, Neubert T, Beaumont K, Turnbull A, Kallel A, Vought B, Stamos D. Correlation between chemotype-dependent binding conformations of HSP90alpha/beta and isoform selectivity-Implications for the structure-based design of HSP90alpha/beta selective inhibitors for treating neurodegenerative diseases. Bioorg Med Chem Lett. 2014 Jan 1;24(1):204-8. doi: 10.1016/j.bmcl.2013.11.036., Epub 2013 Nov 23. PMID:24332488 doi:http://dx.doi.org/10.1016/j.bmcl.2013.11.036
  1. ↑ Christianson JC, Shaler TA, Tyler RE, Kopito RR. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol. 2008 Mar;10(3):272-82. doi: 10.1038/ncb1689. Epub 2008 Feb 10. PMID:18264092 doi:http://dx.doi.org/10.1038/ncb1689

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