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4by0
From Proteopedia
(Difference between revisions)
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| - | + | {{STRUCTURE_4by0| PDB=4by0 | SCENE= }} | |
| + | ===Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'- difluoro-(1,1'-biphenyl)-4-carboxamide=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512] | ||
| - | + | ==About this Structure== | |
| + | [[4by0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY0 OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Sterol 14-demethylase]] | ||
| + | [[Category: Calvet, C M.]] | ||
| + | [[Category: Cameron, M D.]] | ||
| + | [[Category: Choi, J Y.]] | ||
| + | [[Category: Gunatilleke, S S.]] | ||
| + | [[Category: McKerrow, J H.]] | ||
| + | [[Category: Podust, L M.]] | ||
| + | [[Category: Roush, W R.]] | ||
| + | [[Category: Vierira, D F.]] | ||
| + | [[Category: Chagas disease]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Sterol 14-demethylase]] | ||
| + | [[Category: Sterol biosynthesis]] | ||
Revision as of 07:00, 22 January 2014
Contents |
Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'- difluoro-(1,1'-biphenyl)-4-carboxamide
Function
[CP51_TRYCC] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.[1] [UniProtKB:P0A512]
About this Structure
4by0 is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. J Biol Chem. 2006 Feb 10;281(6):3577-85. Epub 2005 Nov 30. PMID:16321980 doi:M510317200
