4m11

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'''Unreleased structure'''
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{{STRUCTURE_4m11| PDB=4m11 | SCENE= }}
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===Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam===
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The entry 4m11 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
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Authors: Xu, S., Banerjee, S., Hermanson, D.J., Marnett, L.J.
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==About this Structure==
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[[4m11]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M11 OCA].
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Description: Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Prostaglandin-endoperoxide synthase]]
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[[Category: Banerjee, S.]]
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[[Category: Hermanson, D J.]]
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[[Category: Marnett, L J.]]
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[[Category: Xu, S.]]
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[[Category: Cox]]
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[[Category: Dioxygenase]]
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[[Category: Glycosylation]]
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[[Category: Nsaid]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Peroxidase]]

Revision as of 07:04, 22 January 2014

Template:STRUCTURE 4m11

Contents

Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam

Function

[PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.[1] [2] [3] [4]

About this Structure

4m11 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ. A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem. 2003 Nov 14;278(46):45763-9. Epub 2003 Aug 18. PMID:12925531 doi:http://dx.doi.org/10.1074/jbc.M305481200
  2. ↑ Vecchio AJ, Simmons DM, Malkowski MG. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63. Epub 2010 May 12. PMID:20463020 doi:10.1074/jbc.M110.119867
  3. ↑ Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem. 2010 Nov 5;285(45):34950-9. Epub 2010 Sep 1. PMID:20810665 doi:10.1074/jbc.M110.162982
  4. ↑ Vecchio AJ, Malkowski MG. The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. J Biol Chem. 2011 Jun 10;286(23):20736-45. Epub 2011 Apr 13. PMID:21489986 doi:10.1074/jbc.M111.230367

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